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Application of IL-2 therapy to target T regulatory cell function
Application of IL-2 therapy to target. T regulatory cell function. Ethan M. Shevach. Laboratory of Immunology, National Institutes of Allergy and Infectious ...

Interleukin 2 (IL-2) therapy: potential - Cancer Treatment Reviews
patients: IL-2 therapy has resulted mainly in about. 20% objective responses in metastasized malignant melanoma and renal cell carcinoma patients, most.

High Dose Interleukin-2 (IL-2) - Stanford Health Library
Interleukin-2 (aldesleukin) is a form of immunotherapy that uses the body's natural immune ... You will receive your interleukin-2 (IL-2) treatment in the hospital.

IL-2 therapy restores regulatory T-cell dysfunction induced by
May 31, 2017 ... enhances the pool of suppressive Treg subsets while effectively con- trolling cytopathic T cells. regulatory T cells | transplantation | IL-2 therapy ...

Treg Cells in IL-2 Therapy - BD Biosciences
Treg Cells in IL-2 Therapy. By Sheng Wu. Currently, high-dose (HD) IL-2 therapy for Stage IV melanoma can induce clinical responses in up to 15% of patients ...

Local and Systemic Effects during Interleukin-2 Therapy of Mouse
[CANCER RESEARCH 47, 4296-4298, August 15, 1987]. Local and Systemic Effects during Interleukin-2 Therapy of Mouse. Mammary Tumors1. Jan Vaage2.

High-Dose Interleukin-2 Therapy - Nebraska Cancer Specialists
Sep 29, 2016 ... Contemporary experience with high‑dose interleukin‑2 therapy and impact on survival in patients with metastatic melanoma and metastatic ...

Low-Dose Interleukin-2 Therapy: A Driver of an Imbalance between
Oct 15, 2014 ... Additionally, we present up-to-date preclinical and clinical studies on low-dose IL -2-based therapy of autoimmune disorders, and focus special ...

Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell
Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of ...

Long-term effects of intermittent interleukin 2 therapy - Blood Journal
IMMUNOBIOLOGY. Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4 /CD25 T cells.

Targeted Interleukin-2 Therapy for Spontaneous - Oxford Academic
and liver, and 2) to assess anti-GD2-targeted IL-2 therapy in this model. Methods: A hybrid neuroblastoma cell line was used to generate the GD2-positive NXS2 ...

Pure Red Cell Aplasia Following Interleukin-2 Therapy
as a result of therapy with high-dose interleukin-2 (IL-2) for metastatic renal cell cancer (RCC). To our knowledge, this is the first report of PRCA as a result of ...

Cardiomyopathy Associated With High-Dose Interleukin-2 Therapy
Hyperthyroxinemia in patients with acute psychiatric disorders. Am J Med 1982;. 73:4147. Cardiomyopathy Associated With. High-Dose Interleukin-2 Therapy.

With Metastatic Cancer Treated With High-Dose Interleukin-2 - NCBI
Treatment with high-dose bolus IL-2 mediates complete can- cer regression in approximately 8% of patients with metastatic renal cancer and melanoma.

Interleukin-2 Therapy of Cancer
of IL-2 therapy of cancer two decades after the first experiments and to discuss whether and which results of local, systemic and adjuvant IL-2 therapy in ...

Rational Interleukin 2 Therapy for HIV Positive Individuals - jstor
IL-2 doses should circumvent toxicity. Therefore, to identify a nontoxic, but effective and safe IL-2 treatment regimen that does not stimulate viral replication,  ...

Efficacy, durability, and response predictors of low-dose interleukin
Apr 12, 2016 ... in active cGVHD. Low-dose IL-2 therapy augmented Treg in-vivo and was associated with clinical improvement. In the current phase 2 study, ...

Serum CD25 Levels During Interleukin-2 Therapy: Dose
Serum CD25 Levels During Interleukin-2 Therapy: Dose. Dependence and Correlations with Clinical Toxicity and. Lymphocyte Surface sCD25 Expression.
1992 - Serum CD25 levels during Interleukin-2 therapy - Dose dependence and correlations with clinical toxicity and lymphocyte surface sCD25 expression.pdf

Rapamycin/IL-2 Combination Therapy in Patients With Type 1
Rapamycin/IL-2 Combination Therapy in Patients With. Type 1 Diabetes Augments Tregs yet Transiently Impairs b-Cell Function. S. Alice Long,1 Mary Rieck,1 ...

Polyethylene glycolated interleukin-2 as maintenance therapy for
19-65 years were treated with polyethylene glycolated interleukin-2 (PEG IL-2), 1 x lo6. U/M2 IV weekly as the sole postremission therapy. Second remission ...